Base excision and single strand break repair
| PAG Title | Base excision and single strand break repair |
| PAG ID | WIG001823 |
| Type | P |
| Source Link |  Spike |
| Publication Reference | NA |
| PAG Description | Base excision repair (BER) is primarily responsible for removing small, non-helix distorting base lesions from the genome. These lesions are resulting from various chemical processes: oxygenations, deaminations, alkylations, and spontaneous hydrolysis of the N-glycosidic bond of the bases. BER is initiated by DNA glycosylases, which recognize and remove specific damaged or inappropriate bases, forming apurinic/apyrimidinic (AP) sites. These are then cleaved by an AP endonuclease or AP DNA lyase. The resulting single-strand break can then be processed by either short-patch (SP-BER) where a single nucleotide is replaced, or long-patch (LP-BER), where 2-10 new nucleotides are synthesized.by a DNA polymerase, The final step of BER entails ligation of the remaining nick, by either LIG1 alone or LIG3–XRCC1 complex. |
| Species | Homo sapiens |
| nCoCo Score | 1,622 |
| Base PAG ID | WIG001823 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
">
Something else? Please send us an email!